Sentinel-2 image mosaic of Brazilian Yanomami Indigenous Territory with 10m of spatial resolution. The mosaic was prepared to support the partnership between the INPE's Health Information Investigation Laboratory (LiSS) and the ICIT-FIOCRUZ Health Information Laboratory (LIS) a multi-institutional body coordinated by Fiocruz and the ministry of health, by creating a health situation database of the Yanomami Indigenous Land. The false color composition is based on the MSI bands 11, 8A and 4 assigned to RGB channels. The temporal composition encompasses 06-months of images, starting in April 2019 and ending in September 2022, with a best pixel selection approach called Least Cloud Cover First (LCF). More information on LCF can be found at Brazil Data Cube web site ( https://brazil-data-cube.github.io/specifications/processing-flow.html#temporal-compositing). This Image Mosaic used more than 15000 Sentinel-2 scenes and was generated based on an existing data cube of Sentinel-2 images.